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通过静态吸附与解吸试验从4种大孔树脂中筛选出AB-8树脂，优化AB-8树脂对吴茱萸总生物碱的纯化工艺，研究AB-8树脂对吴茱萸总生物碱的吸附行为，建立等温吸附模型和吸附动力学模型以探究其吸附过程。结果表明：AB-8树脂对吴茱萸总生物碱的吸附能力优于其他树脂，优化后的纯化工艺参数为进样液浓度16µg/mL、体积5 mL、流速3.0 mL/min，洗脱剂(乙醇)浓度50%、体积50 mL、流速3.0 mL/min，此条件下的吸附率和解吸率分别达82.94%和91.61%；吸附热力学研究表明，其吸附为吸热过程，Freundlich模型能更好地描述其等温吸附过程；AB-8对吴茱萸总生物碱的吸附在8 h后达到平衡，吸附过程符合准二级动力学模型，且吸附过程受液膜与颗粒内扩散共同影响。相关动力学和热力学研究结果为吴茱萸总生物碱的纯化提供了理论指导和科学依据。
Abstract：AB-8 macroporous resin was evaluated for its efficacy in adsorbing and desorbing alkaloids from Euodiae Fructus, through static adsorption and desorption methods. The optimization of purification process for these alkaloids was conducted, focusing on the adsorption behavior of the AB-8 resin. Isothermal adsorption and adsorption kinetic models were established to elucidate the adsorption process. The results indicated that AB-8 resin exhibited superior adsorption capacity for alkaloids derived from Euodiae Fructus. The optimized parameters for the purification process included an injection concentration of 16 µg/mL, a volume of 5 mL, and a flow rate of 3.0 mL/min, achieving an adsorption rate of 82.94%. For desorption, an ethanol elution concentration of 50%, a volume of 50 mL, and a flow rate of 3.0 mL/min resulted in a desorption rate of 91.61%. Thermodynamic studies revealed that the adsorption process was endothermic, and the Freundlich model provided a better fit for the isothermal adsorption process. The adsorption of alkaloids by AB-8 reached equilibrium after 8 h. The kinetics of the adsorption process conformed to a quasi-second-order kinetic model and was influenced by both liquid film and particle diffusion. The kinetic and thermodynamic findings offer theoretical guidance and a scientific basis for the purification of alkaloids from Euodiae Fructus.
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基本信息:
DOI：10.16026/j.cnki.iea.2026020147
中图分类号:TQ464.4;O647.3
引用信息:
[1]裴录,密成杰,王楠,等.大孔树脂对吴茱萸总生物碱的吸附动力学与热力学研究[J].离子交换与吸附,2026,42(02):147-153.DOI:10.16026/j.cnki.iea.2026020147.
基金信息:
黑龙江省省属高校基本科研业务费项目（项目号1452MSYQN008）; 牡丹江师范学院高等教育教学改革研究项目（项目号25-XJ012）;牡丹江师范学院科研项目（项目号MNUB201710）
2026-04-20
2026-04-20