| 145 | 0 | 152 |
| 下载次数 | 被引频次 | 阅读次数 |
采用复配分散体系和超速搅拌悬浮聚合工艺,合成粒径20~40μm的窄分散St/DVB微球,经磺化、纯化、化学修饰和Y3+标记,检测其粒径分布及其在生理环境下Y3+的稳定性与生物相容性。结果显示,微球呈淡黄色,经湿态水流筛分后粒径在20~40μm范围的占比>95%,湿态交换容量为2.0mmol/m L,Y3+标记量为5.0μg/m L,静态标记率为99.6%,在不同浓度浸提液中培养48h,细胞(L929)相对存活率101%~107%;在生理盐水中240h微球内Y3+的渗出率<0.01%,满足常规介入放疗载体所标记放射性元素渗出流失率不高于0.1%的要求。
Abstract：A narrow dispersed St/DVB microsphere with particle size of 20~40μm was synthesized by compound dispersion system and overspeed agitation suspension polymerization process. After sulfonation, purification, chemical modification and Y3+ labeling, we examined the particle size distribution, adsorption stability of Y3+ and biocompatibility. The results showed that the microsphere was pale yellow. After wet flow screening, the size of the particles ranged from 20~40μm, accounting for >95%, and the wet exchange capacity was 2 mmol/m L, Y3+labeled amount of 5μg/m L, the static marking rate is 99.6%. The cell(L929) relative survival rate were 101%~107% after cultured in different concentration extracts for 48 h. In the normal saline storage for 240 h, the exudation rate of Y3+ was <0.015%, which satisfied the requirement of the loss rate of radioactive elements labeled by conventional interventional radiotherapy carriers not higher than 0.1%. It is expected that it can be used as an embolic agent for interventional radiotherapy for advanced liver cancer patients after 60 Co radiation is endowed with radioactivity.
[1]杜荣荣,刘祥.反相微乳液聚合制备丙烯酰胺类聚合物微球的研究进展.化工进展[J].2015,34(8):3065-3074.
[2]张凯,雷毅,王宇光,等.单分散聚苯乙烯微球的制备及影响因素研究.功能高分子学报[J].2002,15(2):189-193.
[3]赵莹,张以举,孙永懋,等.分散聚合法制备窄分布聚苯乙烯微球.应用化学[J].1998,(5):62-64.
[4]江兵兵,张洪涛.分散聚合法制备微米级聚苯乙烯微球.胶体与聚合物[J].2000,18(4):31-34.
[5]王胜广,于洁,刘云云,等.单分散微米级聚苯乙烯微球的制备.功能材料与器件学报[J].2011,17(1):98-106.
[6]戈成彪,康宏亮,董风英,等.室温沉淀聚合制备单分散聚苯乙烯微球.高分子学报[J].2016,(1):98-104.
[7]任秀峰,王芬.单分散聚合法制备微米级聚苯乙烯微球.江苏化工[J].2007,35(6):26-28.
[8]孙刚,张富青,王维,等.单分散窄分布聚苯乙烯微球的制备研究.胶体与聚合物[J].2014,32(4):162-164.
[9]李子凡,祁洪飞,刘大博,等.单体引入方式对聚苯乙烯微球粒径分布的影响.航空材料学报[J].2014,34(3):63-68.
[10]杜荣军,王槐三,孙晓珑,等.采用重复互贯聚合用废弃白球末合成凝胶型阳离子交换树脂的研究.离子交换与吸附[J].2003,(1):77-80.
[11]Yang Guangzhi,Liu Yang,Jia Runping,et al.Emulsier-free emulsion polymerization of acrylonitrile in the presence of PMMA seed particles:Appl.Polym Sci[J].2009,112(1):410-414.
[12]孙蓉.种子分散聚合制备PSt/P(St-MAA)微米级功能性聚合物微球的研究[D].硕士学位论文,武汉:湖北大学,2004.
[13]邓楠楠,汪伟,巨晓洁,等.微流控技术操控微尺度液滴及其聚并的研究进展.中国科学:化学[J].2015,45(1):7-15.
[14]任平伟,褚良银.制备单分散复乳的微流体装备技术.化工装备技术[J].2008,29(1):37-40.
[15]张艳,雷建都,林海,等.利用微流控装置制备微球的研究进展.过程工程学报[J].2009,9(5):1028-1034.
[16]马婷婷,孙津生,王运东,等.微通道法制备单分散液滴的研究进展.中国科技论文[J].2013,8(6):512-517.
[17]汪伟,谢锐,巨晓洁,等.微流控法制备新型微颗粒功能材料研究新进展.化工学报[J].2014,65(7):2556-2562.
[18]刘炳祥,吴婷,王振平,等.液滴微流控芯片合成单分散PEG水凝胶微球及其粒径调控.华东理工大学学报(自然科学版)[J].2014,40(2):182-185.
[19]吕春玲,张景林.单分散纳米聚苯乙烯制备及表征.中北大学学报(自然科学版)[J].2010,31(1):604-607.
[20]Oh D H,Balakrishnan P,Oh Y K,et al.Effect of process parameters on nanoemulsion droplet size and distribution in SPG membrane emulsification.Int Pham[J].2011,404(1/2):191-197.
[21]段兰兰,曾繁明,刘悦,等.纳米微球在药物载体领域的研究进展.胶体与聚合物[J].2015,33(4):175-177.
[22]缪阳,陶玲,沈祥春,等.靶向微球在各脏器疾病中的应用研究进展.中国药房[J].2013,24(13):1225-1226.
[23]杨劲松.脉栓塞微球的研究进展.中国现代医生动[J].2008,46(7):71-72.
[24]唐娜,陈爱政,王士斌,等.肺部给药用高分子多孔微球的生物学评价研究进展.科学通报[J].2014,59(16):1487-1496.
[25]付寒,温新国,典灵辉,等.粒径均一单分散载药微球的制备技术及其应用.中国医药工业杂志[J].2011,42(11):856-870.
基本信息:
DOI：10.16026/j.cnki.iea.2018010040
中图分类号:TQ316
引用信息:
[1]王亚宁,王翰,梁洁.磺化St/DVB窄分散微球的合成及其标记微量钇(Y~(3+))的生物相容性研究[J].离子交换与吸附,2018,34(01):40-48.DOI:10.16026/j.cnki.iea.2018010040.
基金信息:
国家重点研发计划(No 2016YFC1103202)