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基于吸附/解吸附分离纯化机制的大孔吸附树脂(Macroprous Adsorption Resin,MAR)是一类重要的高分子聚合物分离材料,已成为中药产业带动面最广的共性技术和关键技术。虽然MAR技术在分离纯化中药中小分子有效成分方面取得了重要进展,但在分离纯化大分子的中药多糖方面还处于起步阶段。近年来,MAR技术在中药多糖分离纯化中的研究与应用逐渐引起国内外研究者的关注。本文综述了国内外利用MAR技术分离纯化中药多糖的研究进展,重点介绍了MAR技术在分离纯化中药多糖的应用状况、吸附机理等方面的研究进展,并展望了MAR技术在中药多糖分离纯化中的应用前景,以期为MAR技术应用于中药多糖的研究和生产提供理论依据和技术参考。
Abstract：Macroporous adsorption resin(MAR), an important polymer separation material, based on adsorption/desorption separation and purification mechanism has become the most widely used general and key technology on traditional Chinese medicine(TCM) industry. Although MAR has made important progress on separation and purification of small and medium molecular active components of TCM, it is still in its infancy in separating and purifying macromolecule TCM polysaccharides. In recent years, the research and application of MAR in TCM polysaccharide separation has attracted the attention of researchers at home and abroad. This paper summarized the research progress on the separation and purification of TCM polysaccharides by MAR technology at home and abroad. The application status and adsorption mechanism of MAR technology in the separation and preparation of TCM polysaccharides were mainly introduced, and the research progress of the novel super macroporous adsorption resin was prospected. It will provide the theoretical basis and technical reference for the research and production of MAR for TCM polysaccharide in the future.
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基本信息:
DOI：10.16026/j.cnki.iea.2020040375
中图分类号:R284.2
引用信息:
[1]孙艳艳,黄冬冬,刘建飞等.大孔吸附树脂技术分离纯化中药多糖的研究进展[J].离子交换与吸附,2020,36(04):375-383.DOI:10.16026/j.cnki.iea.2020040375.
基金信息:
宁夏回族自治区重点研发计划重大重点项目（2019BEF02006）;; 甘肃省重点研发计划项目（18YF1FA126）