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透明质酸是细胞外基质的主要成分之一,参与调节如细胞黏附、增殖和分化等许多细胞生理过程。由其作为基础材料制备的三维网络状水凝胶可在一定程度上模拟细胞外微环境,协同干细胞在组织修复中发挥积极作用。透明质酸水凝胶因其良好的生物相容性和生物活性而得到广泛应用。为了增强透明质酸水凝胶在各类组织损伤中的长效特异性修复,既可设计水凝胶的机械性能等自身特性以达到仿生水平,也可考虑在水凝胶上负载其他活性成分并对其实现可控释放从而达到治疗效果。本文详细阐述了透明质酸水凝胶在皮肤修复、骨修复、软骨修复和中枢神经系统修复中的应用,并对其发展方向进行了展望。
Abstract:Hyaluronic acid is one of the main components of extracellular matrix.It is involved in regulating many cell physiological processes such as cell adhesion,cell proliferation and cell differentiation.A three-dimensional network of hyaluronic acid hydrogels can simulate the extracellular microenvironment to a certain extent,and cooperate with stem cells to promote tissue repair.With good biocompatibility and biological activity,hyaluronic acid hydrogels have been widely used.It is crucial to adjust the mechanical properties of hydrogels to mimic damaged tissues and load bio-active factors onto hydrogels to construct controlled release systems,which enhance the long-term specific repair effect of hyaluronic acid hydrogels.This review will describe the research progress of hyaluronic acid hydrogel in tissue engineering,such as skin wound repair,bone repair,cartilage repair and central nervous system repair,and prospect its development direction.
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基本信息:
DOI:10.16026/j.cnki.iea.2022010087
中图分类号:R318.08
引用信息:
[1]黄佳星,刘语菲,冯丽安,等.透明质酸水凝胶在组织修复中的应用[J].离子交换与吸附,2022,38(01):87-94.DOI:10.16026/j.cnki.iea.2022010087.
基金信息:
国家自然科学基金面上项目(No.31870966); 国家科技部重大专项(No.2020YFA0803701); 天津市重点支撑项目(No.20YFZCSY01020)资助
2022-02-20
2022-02-20