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利用静电纺丝技术制备了由微米级纤维构成的聚己内酯/明胶共混材料。首先,对材料制备过程的一系列因素进行了考察,确定六氟异丙醇为最优溶剂,18%为适宜的浓度,然后对静电纺丝参数进行了细化研究,确定10m L/h为适宜流速,最后,根据上述条件制备了聚己内酯/明胶比例不同的5种材料,并对其基本性能进行了表征。材料具有高孔隙率和良好的纤维形态。随着明胶含量的增大,材料的拉伸力学强度下降,而亲水性逐渐提高。聚己内酯/明胶比例为8:2的材料的力学性能与纯聚己内酯接近,同时亲水性良好,明胶溶出速度适中,有望应用于人工血管的构建。
Abstract：This study prepared porous electrospun materials made of micrometer polycaprolactone(PCL)/gelatin composite fibers. This study determined the electrospinning conditions by first selecting 1,1,1,3,3,3-hexafluoro-2-propanol as a good solvent, then choosing 18% as an proper concentration, and finally deciding 10 m L/h as the flow rate through refinement of electrospinning parameters. Then materials of different PCL/gelatins ratios were prepared and characterized. The materials exhibited high porosity and fine fiber morphology. As the content of gelatin raised, the tensile strength of the materials decreased, while the hydrophilicity increased. The material with a PCL/gelatin of 8:2 had tensile properties similar to those of PCL as well as a good hydrophilicity and a moderate leaching speed of gelatin, and showed potential in the construction of vascular grafts.
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基本信息:
DOI：10.16026/j.cnki.iea.2016060493
中图分类号:TQ340.64
引用信息:
[1]陈思原,王园园,王淑芳.静电纺丝聚己内酯/明胶粗纤维材料的制备和表征[J].离子交换与吸附,2016,32(06):493-500.DOI:10.16026/j.cnki.iea.2016060493.
基金信息:
国家重点基础研究发展计划(973计划)(2012CB725204);; 教育部“创新团队发展计划”(IRT13023);; 天津自然科学基金(13JCYBJC24900);; 药物化学生物学国家重点实验室开放基金(201603007)