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1996, 02,
聚酯型核磁共振造影剂的合成及体外弛豫性能研究
基金项目(Foundation): 国家863高科技项目
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摘要:

本文通过三种甘醇,己二醇和对苯二酚与DTPA双酸酐共聚,合成了五个大分子配体,这些配体与Gd2O3反应制得相应的配合物,配体和配合物都有较好的水溶性。由三种甘醇制得的配体形成的配合物具有比Gd(DTPA)更好的弛豫性能。

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Abstract:

Five macromolecular ligands had been synthesized by copolymerization of diethylenetri-aminepentaacetic dianhydride (DTPAA) with glycols, 1, 6-hexanediol or hydrequinone.Their gadolinium (Ⅲ) complexes were also prepared. All the ligands and gadolinium complexes exhibit good solubility in water. Preliminary study showed that most of macromolecular metal complexes had higher relaxivity as compared to Gd (DTPA).

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参考文献

1Kim,S.K.;Pohost,G.M.;ElgaviO,G.A.IMagnResonMed,1991,22,572Harrison,A.;Walker,CA.;PereiraK.A.;MagnResonImag.1993,11,7613Shreve,P.;Aisen,A.M.;MagnResonMed,1986,3,3364Wiegers,C.B.IWelch,M.J·;SharP,T.L.IMag。R。。n.J。ag,1992,10,9035Eckelman,W.C.;Karesh,S、M.;Reba,R.C.;J.Pharm.Set,1975,64,7046Lauffer,R.B.;ChemRev,1987,87,901

基本信息:

中图分类号:R981.9

引用信息:

[1]柏正武,卓仁禧,徐勉懿.聚酯型核磁共振造影剂的合成及体外弛豫性能研究[J].离子交换与吸附,1996(02).

基金信息:

国家863高科技项目

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