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为有效提高药物治疗效果,降低毒副作用,基于介孔二氧化硅制备的刺激响应性智能纳米载药系统引起人们的极大关注。以生物相容性的介孔二氧化硅纳米粒子(MSN)作为药物载体,以不同活性端基的官能团硅烷偶联剂做连接体,自组装修饰在MSN表面,并进一步将功能化合物、酶等结合到MSN表面,从而将药物封装在MSN孔道内,构成纳米"阀门"。此类纳米载药系统在pH值、氧化还原、酶等条件刺激下能够实现药物控制释放,在肿瘤疾病靶向治疗方面具有广泛的应用前景。
Abstract:In order to effectively improve the therapeutic effect of drugs and reduce the toxic effects, stimuli-responsive nanocarriers based on mesoporous silica has aroused great concerns. Using biocompatible mesoporous silica nanoparticles(MSN) as the drug carrier, the silane coupling agent with different active terminal groups can be used as the linker to self-assemble and decorate the MSN surface. The functional compounds, enzymes, and other active functional group are incorporated into the MSN surface, encapsulating the drug within MSN tunnel to form a nano-valve. These nanocarriers were controlled by pH, redox, enzymes and other conditions with the application prospect in the treatment of anticancer diseases.
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基本信息:
DOI:10.16026/j.cnki.iea.2019040375
中图分类号:TQ460.4;TB383.1
引用信息:
[1]郭峰,周在帅,王洪生,等.介孔氧化硅纳米粒子在智能药物载体方面的应用[J].离子交换与吸附,2019,35(04):375-384.DOI:10.16026/j.cnki.iea.2019040375.
基金信息:
国家自然科学基金项目(51403096)资助