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形貌适应性多肽组装体作为新型生物医用材料，由于其动态组装特性与精准刺激响应能力，在生物医学领域展现出独特优势。文章系统综述多肽组装形貌转变的分子机制，阐述氢键、疏水作用及π-π堆积作用等非共价力对形貌调控的关键作用。聚焦pH值、酶及氧化还原物质等内源性刺激，揭示了生物微环境对组装形貌动态调控的分子机制，进一步探讨形貌适应性多肽组装体在肿瘤靶向递送、组织工程及生物成像中的应用。该材料通过纳米结构原位形貌转变实现药物精准释放、细胞外基质重构及成像信号放大，显著提升治疗与诊断效能。尽管临床转化仍面临清晰结构表征与规模化制备的挑战，但其精准的生物适配性为下一代生物材料设计提供了革新方法。
Abstract：Morphology-adaptable assemblies of peptides, as a new category of biomaterials, exhibit unique advantages in biomedical applications due to their dynamic structural feature and precise stimuli-responsiveness. This review systematically summarizes the molecular mechanisms of morphological transformation in peptide assembly, elucidated the critical roles of non-covalent interactions, including hydrogen bonding, hydrophobic effects, and π-π stacking, in morphology regulation. Focusing on endogenous stimuli such as pH value, enzymes, and redox gradients, uncover the mechanisms by which biological microenvironments regulate assembly processes, highlight the applications of morphology-adaptable peptide assemblies in tumor-targeted drug delivery, tissue engineering, and bioimaging. These systems are featured by spatiotemporal drug release, extracellular matrix remodeling, and signal amplification through in situ morphological transformations, thereby significantly enhancing therapeutic and diagnostic efficacy. Despite challenges in clinical translation regarding precise characterizations and scalable production, the precise adaptability of these peptide assemblies provides paradigmshifting strategies for design of next-generation biomaterials.
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基本信息:
DOI：10.16026/j.cnki.iea.2025050418
中图分类号:R318.08
引用信息:
[1]王淑雅,余志林.形貌适应性多肽组装生物医用材料[J].离子交换与吸附,2025,41(05):418-431.DOI:10.16026/j.cnki.iea.2025050418.
基金信息:
国家自然科学基金(项目号52273130)