离子交换与吸附

以马铃薯淀粉为原材料,水-乙醇为溶剂制备了羧甲基淀粉(CMS)。通过反相微乳液法包埋阿司匹林制备了载药羧甲基淀粉微球。通过热重、X-衍射以及扫描电镜对羧甲基淀粉进行了表征。结果显示,淀粉经过羧甲基改性后结晶度降低,聚集形态变得更加不规则,说明淀粉羧甲基后在水相中溶解度增大,有利于制备淀粉微球。将羧甲基淀粉与阿司匹林溶于水中,配成浓度为8%的水相溶液。以环己烷与氯仿的混合溶剂(V_环己烷:V_氯仿=3:1)作为油相体系,经过反相乳化成球,实现了对阿司匹林的包埋。羧甲基淀粉微球经载药后呈圆形,表面光滑,粒径为200~800nm,且实现了在不同p H值溶液中对小分子药物的控制释放。有望用于口服药的载体,实现在体内的控制释放,从而增加药物利用率以及降低药物的副作用。

Carboxymethyl starch(CMS) was synthesized by using the potato starch as raw material in water-ethanol mixture solvents. Carboxymethyl starch microspheres embedding aspirin were prepared by the reverse emulsion method. Carboxymethyl starch was characterized by thermogravimetric(TG), X-ray diffraction(XRD) and transmission electron microscopy(TEM). The crystallinity of carboxymethyl starch whit irregular aggregation morphology was lower than that of starch. The solubility of carboxymethyl starch in the aqueous was increased, which would be conducive to prepare starch microspheres. 8% aqueous solution consists of carboxymethyl starch and aspirin in water, and the oil phase consists of the chloroform/cyclohexane(Vcyclohexane:Vchloroform=3:1) mixture solvents. Carboxymethyl starch microspheres as drug carriers were prepared in the aqueous solution/oil phase system by the reverse emulsion method. Carboxymethyl starch microspheres with a smooth surface was a sphere in shape, with a diameter of 200~800nm. Aspirin was controlled release in various pH solvents by carboxymethyl starch microspheres. It is expected that carboxymethyl starch microspheres could be used as a carrier for oral administration in Vivo, and improved the availability of drug and reduced the side effects of drug.