| 135 | 1 | 169 |
| 下载次数 | 被引频次 | 阅读次数 |
酰腙类化合物含有-CO-NH-N=CH-特殊结构,通常是由醛或酮与酰肼通过缩合反应制备,因其药理活性而引起人们的广泛注意。本文在强酸性阳离子交换树脂NKC-9催化条件下,采用醛/酮与苯甲酰肼进行反应,合成了11个苯甲酰腙类化合物。反应过程通过TLC跟踪,产物以FT-IR、~1H-NMR等手段进行表征。催化剂经过简单处理可重复使用。
Abstract：Hydrazones with functional groups of-CO-NH-N=CH-were usually prepared via condensation of aldehydes or ketones with hydrazines.They were well known for their pharmacological activities.In this article,11 kinds of benzoyl hydrazones were synthesized by reaction of aldehydes/ketones and benzoyl hydrazine with strong acid resin of NKC-9 as catalyst in water.The process was traced by TLC and the products were characterized by melting point,FT-IR and ~1H-NMR.The catalyst showed higher catalytic activity and reusability.
[1]吴粦华,拓宏桂,钟春龙.2-羟基-1-萘甲醛缩-2-萘甲酰腙对Zn2+的选择性识别.应用化学[J].2010,27(6):632-636.
[2]Jin Y X,Zhong A G,Zhang Y J,et al.Synthesis,crystal structure,spectroscopic properties,antibacterial activity and theoretical studies of a novel difunctional acylhydrazone.Journal of Molecular Structure[J].2011,1002(10):45-50.
[3]Melnyk P,Leroux V,Sergheraerta C,et al.Design,synthesis and in vitro antimalarial activity of an acylhydrazone library.Bioorganic Medicinal Chemistry Letters[J].2006,16(9):31-35.
[4]Ventura C,Martins F.Application of quantitative structure-activity relationships to the modeling of antitubercular compounds.1.The hydrazide family.Journal of Medicinal Chemistry[J].2008,51(1):612-614.
[5]Kücükgüzel S G,Rollas S,Erdeniz H,et al.Synthesis,characterization and pharmacological properties of some 4-arylhydrazono-2-pyrazoline-5-one derivatives obtained from heterocyclic amines.European Journal of Medicinal Chemistry[J].2000,35(7/8):761-771.
[6]Dimmock J R,Vashishtha S C,Stables J P.Anticonvulsant properties of various acetylhydrazones,oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds.European Journal of Medicinal Chemistry[J].2000,35(2):241-248.
[7]倪振杰,薛思佳,王静,等.1-取代哌啶-4-酮芳甲酰腙的合成及其抗白血病活性.有机化学[J].2011,31(2):222-226.
[8]李清寒,赵志刚.微波辐射下2-[4-二-(4-氟苯)甲基]哌嗪乙酰腙化合物的合成.有机化学[J].2009,29(1):119-122.
[9]石培育,刘玲玲,李晓蕊,等.新的芳杂环酰腙分子钳的微波无溶剂快速有效合成.有机化学[J].2010,30(6):871-876.
[10]魏太保,张治仁,师海雄,等.微波诱导下2-芳氧甲基苯并咪唑-1-水杨醛乙酰腙衍生物合成及生物活性研究有机化学.有机化学[J].2008,28(1):145-150.
[11]程海波,陈学思,肖海华,等.多臂聚乳酸对线型聚乳酸结晶的促进作用.应用化学[J].2010,27(7):754-758.
[12]万婧,秦慧敏,宋国伟,等.固体酸Amberlyst-15催化合成芳香醛邻苯二甲酰腙化合物.化学试剂[J].2010,32(4):308-310.
[13]俞善信,张鲁西.强酸性阳离子交换树脂催化合成丁二酸二丁酯.工业催化[J].2004,12(3):36-37.
[14]孙福安,赵慧,何明阳,等.聚(邻氯苯乙烯-二乙烯基苯)强酸性阳离子交换树脂催化丁烯水合工艺.离子交换与吸附[J].2013,29(1):34-42.
[15]潘佳佳,张贝克,卢秉南.强酸性阳离子交换树脂催化酯化丙烯酸和甲醇合成丙烯酸甲酯的反应动力学.应用化学[J].2014,31(2):171-176.
基本信息:
DOI：10.16026/j.cnki.iea.2016030253
中图分类号:TQ24
引用信息:
[1]王慧彦,孟瑶,季媛媛,等.水相中苯甲酰腙类化合物的绿色合成[J].离子交换与吸附,2016,32(03):253-261.DOI:10.16026/j.cnki.iea.2016030253.
基金信息:
江苏省海洋资源开发研究院开放课题基金项目(批准号JSIMR201304);; 江苏省高等学校大学生创新创业训练计划省级指导项目(批准号201411641083X)
2016-06-20
2016-06-20